An expedient one-pot synthesis for protected 2-thia-5-azabicyclo[2.2.1]heptan-3-ones. Versatile intermediates in the synthesis of carbapenem sidechains

K. M.J. Brands, G. Marchesini, J. M. Williams, U. H. Dolling, P. J. Reider

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A convenient and high yielding one-pot process for the preparation of protected 2-thia-5-azabicyclo-[2.2.1]heptan-3-ones from 4-hydroxyproline and their use in the synthesis of carbapenem sidechains is described.

Original languageEnglish (US)
Pages (from-to)2919-2922
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number17
DOIs
StatePublished - Apr 22 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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