Abstract
An azaspiroannulation and an uncommon Mitsunobu reaction are the key steps in a convergent, enantioselective synthesis of the title compound 1. This potent immunosuppressant is derived from a fungus and is distinguished by an unusual monophosphate ester group and a novel architecture which comprises most of the atoms of two molecules of tyrosine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4593-4596 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 39 |
| Issue number | 24 |
| DOIs | |
| State | Published - Dec 15 2000 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry
Keywords
- Annulations
- Natural products
- Nitrogen heterocycles
- Polycycles
- Total synthesis