An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

Lushi Tan; Cheng Yi Chen; Robert D. Larsen; Thomas R. Verhoeven; Paul J. Reider

doi:10.1016/S0040-4039(98)00735-7

An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

Lushi Tan, Cheng Yi Chen, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.

Original language	English (US)
Pages (from-to)	3961-3964
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	23
DOIs	https://doi.org/10.1016/S0040-4039(98)00735-7
State	Published - Jun 4 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)00735-7

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title = "An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512",

abstract = "An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.",

author = "Lushi Tan and Chen, {Cheng Yi} and Larsen, {Robert D.} and Verhoeven, {Thomas R.} and Reider, {Paul J.}",

year = "1998",

month = jun,

day = "4",

doi = "10.1016/S0040-4039(98)00735-7",

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T1 - An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

AU - Tan, Lushi

AU - Chen, Cheng Yi

AU - Larsen, Robert D.

AU - Verhoeven, Thomas R.

AU - Reider, Paul J.

PY - 1998/6/4

Y1 - 1998/6/4

N2 - An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.

AB - An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.

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UR - http://www.scopus.com/inward/citedby.url?scp=0032482530&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(98)00735-7

DO - 10.1016/S0040-4039(98)00735-7

M3 - Article

AN - SCOPUS:0032482530

SN - 0040-4039

VL - 39

SP - 3961

EP - 3964

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 23

ER -

An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

Abstract

All Science Journal Classification (ASJC) codes

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