An efficient asymmetric synthesis of a potent COX-2 inhibitor L-784,512

Lushi Tan, Cheng Yi Chen, Robert D. Larsen, Thomas R. Verhoeven, Paul J. Reider

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

An efficient enantioselective synthesis of L-784,512 featuring a Horner- Emmons reaction, a new one-pot trifluoromethylation, and the Sharpless asymmetric dihydroxylation is described.

Original languageEnglish (US)
Pages (from-to)3961-3964
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number23
DOIs
StatePublished - Jun 4 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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