An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan® piperazine intermediate

K. Rossen; P. J. Pye; L. M. DiMichele; R. P. Volante; P. J. Reider

doi:10.1016/S0040-4039(98)01484-1

An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan® piperazine intermediate

K. Rossen
, P. J. Pye
, L. M. DiMichele
, R. P. Volante
, P. J. Reider

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The Crixivan® HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.

Original language	English (US)
Pages (from-to)	6823-6826
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	38
DOIs	https://doi.org/10.1016/S0040-4039(98)01484-1
State	Published - Sep 17 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)01484-1

Cite this

@article{376a40e7a4a1483cb11e8c280078714c,

title = "An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan{\textregistered} piperazine intermediate",

abstract = "The Crixivan{\textregistered} HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.",

author = "K. Rossen and Pye, \{P. J.\} and DiMichele, \{L. M.\} and Volante, \{R. P.\} and Reider, \{P. J.\}",

year = "1998",

month = sep,

day = "17",

doi = "10.1016/S0040-4039(98)01484-1",

language = "English (US)",

volume = "39",

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journal = "Tetrahedron Letters",

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T1 - An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan® piperazine intermediate

AU - Rossen, K.

AU - Pye, P. J.

AU - DiMichele, L. M.

AU - Volante, R. P.

AU - Reider, P. J.

PY - 1998/9/17

Y1 - 1998/9/17

N2 - The Crixivan® HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.

AB - The Crixivan® HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.

UR - https://www.scopus.com/pages/publications/0032541686

UR - https://www.scopus.com/pages/publications/0032541686#tab=citedBy

U2 - 10.1016/S0040-4039(98)01484-1

DO - 10.1016/S0040-4039(98)01484-1

M3 - Article

AN - SCOPUS:0032541686

SN - 0040-4039

VL - 39

SP - 6823

EP - 6826

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan® piperazine intermediate

Abstract

All Science Journal Classification (ASJC) codes

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