An efficient asymmetric hydrogenation approach to the synthesis of the Crixivan® piperazine intermediate

K. Rossen, P. J. Pye, L. M. DiMichele, R. P. Volante, P. J. Reider

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

The Crixivan® HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.

Original languageEnglish (US)
Pages (from-to)6823-6826
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number38
DOIs
StatePublished - Sep 17 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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