The Crixivan® HIV protease inhibitor piperazine intermediate 2 was prepared by a four step sequence using a chiral hydrogenation of the tetrahydropyrazine 9 to establish the absolute stereochemistry.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 17 1998|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry