TY - JOUR
T1 - An adenovirus type 5 early gene function regulates expression of other early viral genes
AU - Jones, N.
AU - Shenk, T.
PY - 1979
Y1 - 1979
N2 - We have identified an adenovirus type 5 (Ad5) early gene function located in early region I which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human in embryonic kidney cells), but its growth is severely restricted in HeLa cells. We detect no viral RNAs in the cytoplasm of dl312-infected HeLa cells. Viral RNA sequences are present, however, in dl312-infected HeLa cell nuclei.
AB - We have identified an adenovirus type 5 (Ad5) early gene function located in early region I which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human in embryonic kidney cells), but its growth is severely restricted in HeLa cells. We detect no viral RNAs in the cytoplasm of dl312-infected HeLa cells. Viral RNA sequences are present, however, in dl312-infected HeLa cell nuclei.
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U2 - 10.1073/pnas.76.8.3665
DO - 10.1073/pnas.76.8.3665
M3 - Article
C2 - 291030
AN - SCOPUS:0018650016
SN - 0027-8424
VL - 76
SP - 3665
EP - 3669
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 8
ER -