An adenovirus type 5 early gene function regulates expression of other early viral genes

N. Jones, T. Shenk

Research output: Contribution to journalArticle

369 Scopus citations

Abstract

We have identified an adenovirus type 5 (Ad5) early gene function located in early region I which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human in embryonic kidney cells), but its growth is severely restricted in HeLa cells. We detect no viral RNAs in the cytoplasm of dl312-infected HeLa cells. Viral RNA sequences are present, however, in dl312-infected HeLa cell nuclei.

Original languageEnglish (US)
Pages (from-to)3665-3669
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume76
Issue number8
DOIs
StatePublished - 1979

All Science Journal Classification (ASJC) codes

  • General

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