TY - JOUR
T1 - Amino acids and serotonin in Limax maximus after a tryptophan devoid diet
AU - Gietzen, Dorothy W.
AU - Harris, Adam S.
AU - Carlson, Scott
AU - Gelperin, Alan
N1 - Funding Information:
Acknowledgemenrs-Thea uthorsa re gratefult o Dr Q. R. Rogers for the amino acid analyses and to both Dr Rogers and Dr K. Delaney for much advice. We also thank Dan Wong and Stephanie Lee for their help with the amino acid analyses. MS Christiane Wear, MS Peggy Moore, MS Amy Caprile and Mrs Susan Garcia provided invaluable help in caring for and feeding the animals. Portions of these data have been presented in abstract form. This work was supported in part by BRS Grant # 88-2 1 through the Office of the Dean, School of Veterinary Medicine, University of California, Davis, and NIH grant #DK07355 to DWG. The electrophysiological studies were done at the Friday Harbor Laboratories of the University of Washington.
PY - 1992/1
Y1 - 1992/1
N2 - 1. 1. Animals avoid diets lacking an essential amino acid, such as tryptophan (TRP), the precursor for serotonin (5-HT). 5-HT is important in the control of feeding. 2. 2. To study the effects of TRP deprivation, slugs were fed TRP-devoid (DEV) or control (COR) diets. 3. 3. Food intake was depressed in DEV, as expected, but after 2 weeks, the serontonergic metacerebral giant cell in DEV was still functional. 4. 4. Neither brain 5-HT nor plasma TRP concentration was affected. 5. 5. Compared with food-restricted animals that had reductions in most amino acids, the DEV group sustained a marked plasma amino acid imbalance.
AB - 1. 1. Animals avoid diets lacking an essential amino acid, such as tryptophan (TRP), the precursor for serotonin (5-HT). 5-HT is important in the control of feeding. 2. 2. To study the effects of TRP deprivation, slugs were fed TRP-devoid (DEV) or control (COR) diets. 3. 3. Food intake was depressed in DEV, as expected, but after 2 weeks, the serontonergic metacerebral giant cell in DEV was still functional. 4. 4. Neither brain 5-HT nor plasma TRP concentration was affected. 5. 5. Compared with food-restricted animals that had reductions in most amino acids, the DEV group sustained a marked plasma amino acid imbalance.
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U2 - 10.1016/0300-9629(92)90642-4
DO - 10.1016/0300-9629(92)90642-4
M3 - Article
C2 - 1347723
AN - SCOPUS:0026501462
SN - 0300-9629
VL - 101
SP - 143
EP - 149
JO - Comparative Biochemistry and Physiology -- Part A: Physiology
JF - Comparative Biochemistry and Physiology -- Part A: Physiology
IS - 1
ER -