Abstract
The direct α-heteroarylation of tertiary amines has been accomplished via photoredox catalysis to generate valuable benzylic amine pharmacophores. A variety of five- and six-membered chloroheteroarenes are shown to function as viable coupling partners for the α-arylation of a diverse range of cyclic and acyclic amines. Evidence is provided for a homolytic aromatic substitution mechanism, in which a catalytically-generated α-amino radical undergoes direct addition to an electrophilic chloroarene.
Original language | English (US) |
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Pages (from-to) | 4173-4178 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 5 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2014 |
All Science Journal Classification (ASJC) codes
- General Chemistry