Abstract
Alternative splicing of pre-mRNAs is widespread in eukaryotes and provides a key mechanism for generating different gene products, often with distinct or specialized functions, from a single transcription unit. In insects, alternative splicing plays an especially important role in the process of sex determination, providing the mechanism for remembering sexual identity (determination) and for orchestrating sexual development (differentiation).
| Original language | English (US) |
|---|---|
| Title of host publication | Encyclopedia of Biological Chemistry |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 81-86 |
| Number of pages | 6 |
| ISBN (Electronic) | 9780123786319 |
| ISBN (Print) | 9780123786302 |
| DOIs | |
| State | Published - Feb 15 2013 |
All Science Journal Classification (ASJC) codes
- General Biochemistry, Genetics and Molecular Biology
Keywords
- Alternative splicing
- Blockage mechanism
- Doublesex
- Fruitless
- SR proteins
- Sex determination
- Sex lethal
- Splice site activation
- Spliceosome complexes
- Splicing
- Transformer
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