Alternative Splicing: Regulation of Drosophila melanogaster Sex Determination

J. K.M. Penn, P. Graham, P. Schedl, H. K. Salz

Research output: Chapter in Book/Report/Conference proceedingChapter


Alternative splicing of pre-mRNAs is widespread in eukaryotes and provides a key mechanism for generating different gene products, often with distinct or specialized functions, from a single transcription unit. In insects, alternative splicing plays an especially important role in the process of sex determination, providing the mechanism for remembering sexual identity (determination) and for orchestrating sexual development (differentiation).

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
StatePublished - Feb 15 2013

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


  • Alternative splicing
  • Blockage mechanism
  • Doublesex
  • Fruitless
  • SR proteins
  • Sex determination
  • Sex lethal
  • Splice site activation
  • Spliceosome complexes
  • Splicing
  • Transformer


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