Alternate Exon Usage is a Commonly Used Mechanism for Increasing Coding Diversity Within Genes Coding for Extracellular Matrix Proteins

Charles D. Boyd, Richard A. Pierce, Jean E. Schwarzbauer, Kurt Doege, Linda J. Sandell

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Extracellular matrix proteins are a diverse family of secreted proteins and glycoproteins that are responsible for a variety of critical functions in different tissues. A large number of multiexon genes encode these proteins of the extracellular matrix. Over the last few years, it has become evident that the processing of the pre-mRNA from several of these genes involves alternative splicing. This review summarizes the known examples of alternative splicing in genes coding for the extracellular matrix and attempts to relate the increase in coding diversity generated by alternate exon usage to the function(s) of individual extracellular matrix proteins.

Original languageEnglish (US)
Pages (from-to)457-469
Number of pages13
JournalMatrix
Volume13
Issue number6
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Rheumatology

Keywords

  • alternate exon usage
  • coding diversity
  • extracellular matrix proteins.

Fingerprint Dive into the research topics of 'Alternate Exon Usage is a Commonly Used Mechanism for Increasing Coding Diversity Within Genes Coding for Extracellular Matrix Proteins'. Together they form a unique fingerprint.

  • Cite this