Altered topology of neural circuits in congenital prosopagnosia

Gideon Rosenthal, Michal Tanzer, Erez Simony, Uri Hasson, Marlene Behrmann, Galia Avidan

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Using a novel, fMRI-based inter-subject functional correlation (ISFC) approach, which isolates stimulus-locked inter-regional correlation patterns, we compared the cortical topology of the neural circuit for face processing in participants with an impairment in face recognition, congenital prosopagnosia (CP), and matched controls. Whereas the anterior temporal lobe served as the major network hub for face processing in controls, this was not the case for the CPs. Instead, this group evinced hyper-connectivity in posterior regions of the visual cortex, mostly associated with the lateral occipital and the inferior temporal cortices. Moreover, the extent of this hyperconnectivity was correlated with the face recognition deficit. These results offer new insights into the perturbed cortical topology in CP, which may serve as the underlying neural basis of the behavioral deficits typical of this disorder. The approach adopted here has the potential to uncover altered topologies in other neurodevelopmental disorders, as well.

Original languageEnglish (US)
Article numbere25069
JournaleLife
Volume6
DOIs
StatePublished - Aug 21 2017

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Rosenthal, G., Tanzer, M., Simony, E., Hasson, U., Behrmann, M., & Avidan, G. (2017). Altered topology of neural circuits in congenital prosopagnosia. eLife, 6, [e25069]. https://doi.org/10.7554/eLife.25069