TY - JOUR
T1 - Altered topology of neural circuits in congenital prosopagnosia
AU - Rosenthal, Gideon
AU - Tanzer, Michal
AU - Simony, Erez
AU - Hasson, Uri
AU - Behrmann, Marlene
AU - Avidan, Galia
N1 - Publisher Copyright:
© Rosenthal et al.
PY - 2017/8/21
Y1 - 2017/8/21
N2 - Using a novel, fMRI-based inter-subject functional correlation (ISFC) approach, which isolates stimulus-locked inter-regional correlation patterns, we compared the cortical topology of the neural circuit for face processing in participants with an impairment in face recognition, congenital prosopagnosia (CP), and matched controls. Whereas the anterior temporal lobe served as the major network hub for face processing in controls, this was not the case for the CPs. Instead, this group evinced hyper-connectivity in posterior regions of the visual cortex, mostly associated with the lateral occipital and the inferior temporal cortices. Moreover, the extent of this hyperconnectivity was correlated with the face recognition deficit. These results offer new insights into the perturbed cortical topology in CP, which may serve as the underlying neural basis of the behavioral deficits typical of this disorder. The approach adopted here has the potential to uncover altered topologies in other neurodevelopmental disorders, as well.
AB - Using a novel, fMRI-based inter-subject functional correlation (ISFC) approach, which isolates stimulus-locked inter-regional correlation patterns, we compared the cortical topology of the neural circuit for face processing in participants with an impairment in face recognition, congenital prosopagnosia (CP), and matched controls. Whereas the anterior temporal lobe served as the major network hub for face processing in controls, this was not the case for the CPs. Instead, this group evinced hyper-connectivity in posterior regions of the visual cortex, mostly associated with the lateral occipital and the inferior temporal cortices. Moreover, the extent of this hyperconnectivity was correlated with the face recognition deficit. These results offer new insights into the perturbed cortical topology in CP, which may serve as the underlying neural basis of the behavioral deficits typical of this disorder. The approach adopted here has the potential to uncover altered topologies in other neurodevelopmental disorders, as well.
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U2 - 10.7554/eLife.25069
DO - 10.7554/eLife.25069
M3 - Article
C2 - 28825896
AN - SCOPUS:85029224029
SN - 2050-084X
VL - 6
JO - eLife
JF - eLife
M1 - e25069
ER -