Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity

Eirin Carolan, Laura M. Tobin, Bozgana A. Mangan, Michelle Corrigan, Gadinthsware Gaoatswe, Greg Byrne, Justin Geoghegan, Declan Cody, Jean O'Connell, Desmond C. Winter, Derek G. Doherty, Lydia Lynch, Donal O'Shea, Andrew E. Hogan

Research output: Contribution to journalArticlepeer-review

137 Scopus citations

Abstract

Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through the rapid production of cytokines. In this article, we show that circulating MAIT cells are depleted in obese adults, and depletion is associated with diabetic status. Circulating MAIT cells more frequently produced IL-17 upon stimulation ex vivo, a cytokine implicated in insulin resistance. MAIT cells were enriched in adipose tissue (AT) compared with blood. AT MAIT cells, but not circulating MAIT cells, were capable of producing IL-10. In AT from obese subjects, MAIT cells were depleted, were less likely to produce IL-10, and more frequently produced IL-17. Finally, we show that IL-17+ MAIT cells are also increased in childhood obesity, and altered MAIT cell frequencies in obese children are positively associated with insulin resistance. These data indicate that MAIT cells are enriched in human AT and display an IL-17+ phenotype in both obese adults and children, correlating with levels of insulin resistance. The alterations in MAIT cells may be contributing to obesity-related sterile inflammation and insulin resistance.

Original languageEnglish (US)
Pages (from-to)5775-5780
Number of pages6
JournalJournal of Immunology
Volume194
Issue number12
DOIs
StatePublished - Jun 15 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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