Alterations of serotonin and LSD receptor binding following repeated administration of LSD

Michael E. Trulson, Barry L. Jacobs

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Repeated administration of LSD to rats (100 μg/kg every 6 hours for 4 days) resulted in significant decreases in both the KD (-17 & -23%) and Bmax (-25 %& -30%) for [3H]-5HT binding in forebrain and brainstem plus spinal cord. [3H] - LSD binding showed significant changes in Bmax values (-19%) in forebrain and brainstem plus spinal cord, while KD values were not significantly changed. Neither a single injection of LSD (100 μg/kg) nor repeated administration of brom-LSD (100 μg/kg every 6 hours for 4 days) produced any significant changes in binding. In addition, repeated LSD administration produced no significant changes in [3H] - spiroperidol binding.

Original languageEnglish (US)
Pages (from-to)2053-2061
Number of pages9
JournalLife Sciences
Volume24
Issue number22
DOIs
StatePublished - May 28 1979

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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