Abstract
Repeated administration of LSD to rats (100 μg/kg every 6 hours for 4 days) resulted in significant decreases in both the KD (-17 & -23%) and Bmax (-25 %& -30%) for [3H]-5HT binding in forebrain and brainstem plus spinal cord. [3H] - LSD binding showed significant changes in Bmax values (-19%) in forebrain and brainstem plus spinal cord, while KD values were not significantly changed. Neither a single injection of LSD (100 μg/kg) nor repeated administration of brom-LSD (100 μg/kg every 6 hours for 4 days) produced any significant changes in binding. In addition, repeated LSD administration produced no significant changes in [3H] - spiroperidol binding.
Original language | English (US) |
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Pages (from-to) | 2053-2061 |
Number of pages | 9 |
Journal | Life Sciences |
Volume | 24 |
Issue number | 22 |
DOIs | |
State | Published - May 28 1979 |
All Science Journal Classification (ASJC) codes
- General Pharmacology, Toxicology and Pharmaceutics
- General Biochemistry, Genetics and Molecular Biology