Allosteric Activation of a Bacterial Stress Sensor

Nieng Yan, Yigong Shi

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
JournalCell
Volume131
Issue number3
DOIs
StatePublished - Nov 2 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Allosteric Activation of a Bacterial Stress Sensor'. Together they form a unique fingerprint.

  • Cite this