Allosteric Activation of a Bacterial Stress Sensor

Nieng Yan; Yigong Shi

doi:10.1016/j.cell.2007.10.021

Allosteric Activation of a Bacterial Stress Sensor

Nieng Yan, Yigong Shi

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

Original language	English (US)
Pages (from-to)	441-443
Number of pages	3
Journal	Cell
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2007.10.021
State	Published - Nov 2 2007

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2007.10.021

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title = "Allosteric Activation of a Bacterial Stress Sensor",

abstract = "In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.",

author = "Nieng Yan and Yigong Shi",

year = "2007",

month = nov,

day = "2",

doi = "10.1016/j.cell.2007.10.021",

language = "English (US)",

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T1 - Allosteric Activation of a Bacterial Stress Sensor

AU - Yan, Nieng

AU - Shi, Yigong

PY - 2007/11/2

Y1 - 2007/11/2

N2 - In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

AB - In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

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U2 - 10.1016/j.cell.2007.10.021

DO - 10.1016/j.cell.2007.10.021

M3 - Short survey

C2 - 17981109

AN - SCOPUS:35548949407

SN - 0092-8674

VL - 131

SP - 441

EP - 443

JO - Cell

JF - Cell

IS - 3

ER -

Allosteric Activation of a Bacterial Stress Sensor

Abstract

All Science Journal Classification (ASJC) codes

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