Allosteric Activation of a Bacterial Stress Sensor

Nieng Yan, Yigong Shi

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


In Gram-negative bacteria, envelope stress signals such as unfolded outer membrane proteins (OMP) activate the periplasmic protease DegS. This protease then triggers a cellular pathway to alleviate the stress. Now Sohn et al. (2007) show conclusively that inhibition of DegS is relieved allosterically by binding of the C-terminal sequences in unfolded OMPs to the PDZ domain of DegS.

Original languageEnglish (US)
Pages (from-to)441-443
Number of pages3
Issue number3
StatePublished - Nov 2 2007

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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