Alcohol-alcohol cross-coupling enabled by SH2 radical sorting

Ruizhe Chen, Nicholas E. Intermaggio, Jiaxin Xie, James A. Rossi-Ashton, Colin A. Gould, Robert T. Martin, Jesús Alcázar, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

Abstract

Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp3)–C(sp3) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting–mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.

Original languageEnglish (US)
Pages (from-to)1350-1357
Number of pages8
JournalScience
Volume383
Issue number6689
DOIs
StatePublished - Mar 22 2024

All Science Journal Classification (ASJC) codes

  • General

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