Albusnodin: An acetylated lasso peptide from: Streptomyces albus

Chuhan Zong, Wai Ling Cheung-Lee, Hader E. Elashal, Monika Raj, A. James Link

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

Original languageEnglish (US)
Pages (from-to)1339-1342
Number of pages4
JournalChemical Communications
Volume54
Issue number11
DOIs
StatePublished - 2018

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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