Albusnodin: An acetylated lasso peptide from: Streptomyces albus

Chuhan Zong; Wai Ling Cheung-Lee; Hader E. Elashal; Monika Raj; A. James Link

doi:10.1039/c7cc08620b

Albusnodin: An acetylated lasso peptide from: Streptomyces albus

Chuhan Zong, Wai Ling Cheung-Lee, Hader E. Elashal, Monika Raj, A. James Link

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

Original language	English (US)
Pages (from-to)	1339-1342
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	11
DOIs	https://doi.org/10.1039/c7cc08620b
State	Published - 2018

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.",

author = "Chuhan Zong and Cheung-Lee, {Wai Ling} and Elashal, {Hader E.} and Monika Raj and Link, {A. James}",

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AU - Raj, Monika

AU - Link, A. James

PY - 2018

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AB - We describe a lasso peptide, albusnodin, that is post-translationally modified with an acetyl group, the first example of a lasso peptide with this modification. Using heterologous expression, we further show that the acetyltransferase colocalized with the albusnodin gene cluster is required for the biosynthesis of this lasso peptide. This type of lasso peptide is widespread in Actinobacteria with 44 examples found in currently sequenced genomes.

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Albusnodin: An acetylated lasso peptide from: Streptomyces albus

Abstract

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