Age-related changes in biomarkers: Longitudinal data from a population-based sample

Dana A. Glei, Noreen Goldman, Yu Hsuan Lin, Maxine Weinstein

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Identifying how biological parameters change with age can provide insights into the physiological determinants of disease and, ultimately, death. Most prior studies of age-related change in biomarkers are based on cross-sectional data, small or selective samples, or a limited number of biomarkers. We use data from a nationally representative longitudinal sample of 639 Taiwanese aged 54 and older in 2000 to assess changes over a six-year period in a wide range of biomarkers. Markers that increased most with age were glycoslyated hemoglobin, interleukin-6, and norepinephrine. Markers that decreased most with age were diastolic blood pressure and creatinine clearance. For example, glycoslyated hemoglobin increased by 8% to 13%, depending on sex and age at baseline, over this six-year period. Several standard clinical risk factors exhibited little evidence of age-related change. Further research is needed to determine whether the observed variation between individuals in biomarker changes represents differences in underlying physiological function that are predictive of future health and survival.

Original languageEnglish (US)
Pages (from-to)312-326
Number of pages15
JournalResearch on Aging
Issue number3
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Social Psychology
  • Health(social science)
  • Geriatrics and Gerontology


  • age-related change
  • aging
  • biomarkers
  • longitudinal analysis


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