Advances in AIDS chemotherapy: The asymmetric synthesis of CRIXIVAN®

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Abstract

The discovery and development of an efficient, practical asymmetric synthesis of the HIV Protease inhibitor CRIXIVAN® is described. Particular emphasis is placed on the selective installation of each of the five stereogenic centers as well as design strategies associated with the preparation of a complex pharmaceutical agent needed in multiton quantities.

Original languageEnglish (US)
Pages (from-to)306-308
Number of pages3
JournalChimia
Volume51
Issue number6
StatePublished - 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Chemistry

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