Advances and challenges in studying hepatitis C virus in its native environment

Timothy Sheahan, Christopher T. Jones, Alexander Ploss

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Approximately 2% of the worldwide population is infected with hepatitis C virus (HCV), the major causative agent of non-A, non-B hepatitis. Although substantial progress has been made in developing tools to dissect the viral life cycle, most in vitro studies rely on hepatoma cell lines, which are functionally disparate from the natural in vivo target of the virus - hepatocytes. To gain insights into virus-host interactions, there is a need for HCV-model systems that more closely mimic the physiological environment of the liver. Here, we discuss recent advances in culture and detection systems that facilitate the study of HCV in primary cells. Use of these new models may help bridge the gap between in vitro studies and clinical research.

Original languageEnglish (US)
Pages (from-to)541-550
Number of pages10
JournalExpert Review of Gastroenterology and Hepatology
Issue number5
StatePublished - Oct 2010

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology


  • cell culture systems
  • drug development
  • hepatitis C virus
  • hepatotropic infections
  • liver
  • primary hepatocytes


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