Adult Neurogenesis, Glia, and the Extracellular Matrix

Elise C. Cope, Elizabeth Gould

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations


In this Review, Cope and Gould discuss how the functional consequences of new neurons generated during adult neurogenesis arise from the collective interactions of presynaptic and postsynaptic neurons, glial cells, and the extracellular matrix, which together form the “tetrapartite synapse.”

Original languageEnglish (US)
Pages (from-to)690-705
Number of pages16
JournalCell stem cell
Issue number5
StatePublished - May 2 2019

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Medicine
  • Cell Biology


  • adult neurogenesis
  • astrocytes
  • extracellular matrix
  • hippocampus
  • immature neuron
  • microglia
  • perineuronal nets
  • progenitor cell
  • stem cell


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