Abstract
Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyms in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-93 |
| Number of pages | 3 |
| Journal | Developmental Brain Research |
| Volume | 103 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 20 1997 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Developmental Neuroscience
- Developmental Biology
Keywords
- Adrenal steroid
- Cell death
- Corticosterone
- Dentate gyms
- Development
- NMDA receptor
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