Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

Elizabeth Gould, Patima Tanapat, Heather A. Cameron

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyms in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

Original languageEnglish (US)
Pages (from-to)91-93
Number of pages3
JournalDevelopmental Brain Research
Volume103
Issue number1
DOIs
StatePublished - Oct 20 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Adrenal steroid
  • Cell death
  • Corticosterone
  • Dentate gyms
  • Development
  • NMDA receptor

Fingerprint Dive into the research topics of 'Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism'. Together they form a unique fingerprint.

  • Cite this