Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

Elizabeth Gould; Patima Tanapat; Heather A. Cameron

doi:10.1016/S0165-3806(97)00079-5

Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

Elizabeth Gould, Patima Tanapat, Heather A. Cameron

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyms in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

Original language	English (US)
Pages (from-to)	91-93
Number of pages	3
Journal	Developmental Brain Research
Volume	103
Issue number	1
DOIs	https://doi.org/10.1016/S0165-3806(97)00079-5
State	Published - Oct 20 1997
Externally published	Yes

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

Keywords

Adrenal steroid
Cell death
Corticosterone
Dentate gyms
Development
NMDA receptor

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10.1016/S0165-3806(97)00079-5

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abstract = "Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyms in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.",

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AU - Cameron, Heather A.

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AB - Treatment with the NMDA receptor antagonist MK-801 prevented the adrenal steroid-induced suppression of cell death, determined by both morphological identification of pyknotic cells and TUNEL staining, in the dentate gyms in rat pups. This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation.

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KW - Development

KW - NMDA receptor

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Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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