Adipose and mammary epithelial tissue engineering

Wenting Zhu, Celeste M. Nelson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Breast reconstruction is a type of surgery for women who have had a mastectomy, and involves using autologous tissue or prosthetic material to construct a natural-looking breast. Adipose tissue is the major contributor to the volume of the breast, whereas epithelial cells comprise the functional unit of the mammary gland. Adipose-derived stem cells (ASCs) can differentiate into both adipocytes and epithelial cells and can be acquired from autologous sources. ASCs are therefore an attractive candidate for clinical applications to repair or regenerate the breast. Here we review the current state of adipose tissue engineering methods, including the biomaterials used for adipose tissue engineering and the application of these techniques for mammary epithelial tissue engineering. Adipose tissue engineering combined with microfabrication approaches to engineer the epithelium represents a promising avenue to replicate the native structure of the breast.

Original languageEnglish (US)
JournalBiomatter
Volume3
Issue number3
DOIs
StatePublished - Jul 1 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Keywords

  • 3D
  • mammary epithelium
  • morphogenesis
  • organotypic
  • patterning

Fingerprint Dive into the research topics of 'Adipose and mammary epithelial tissue engineering'. Together they form a unique fingerprint.

Cite this