Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

Bayar Thimmappaya, Cary Weinberger, Robert J. Schneider, Thomas Shenk

Research output: Contribution to journalArticle

216 Scopus citations

Abstract

Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalCell
Volume31
Issue number3 PART 2
DOIs
StatePublished - Dec 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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