Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

Bayar Thimmappaya; Cary Weinberger; Robert J. Schneider; Thomas Shenk

doi:10.1016/0092-8674(82)90310-5

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

Bayar Thimmappaya, Cary Weinberger, Robert J. Schneider, Thomas Shenk

Research output: Contribution to journal › Article › peer-review

256 Scopus citations

Abstract

Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

Original language	English (US)
Pages (from-to)	543-551
Number of pages	9
Journal	Cell
Volume	31
Issue number	3 PART 2
DOIs	https://doi.org/10.1016/0092-8674(82)90310-5
State	Published - Dec 1982

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/0092-8674(82)90310-5

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title = "Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection",

abstract = "Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.",

author = "Bayar Thimmappaya and Cary Weinberger and Schneider, {Robert J.} and Thomas Shenk",

note = "Funding Information: We acknowledge the competent technical assistance of Martha Mar-low. and thank 0. Halbert for assistance with PLC analyses. This work was supported by a grant from the American Cancer Society. R. J. S. is an NIH Postdoctoral Trainee. T. S. is an Established Investigator of the American Heart Association. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "1982",

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doi = "10.1016/0092-8674(82)90310-5",

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T1 - Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

AU - Thimmappaya, Bayar

AU - Weinberger, Cary

AU - Schneider, Robert J.

AU - Shenk, Thomas

N1 - Funding Information: We acknowledge the competent technical assistance of Martha Mar-low. and thank 0. Halbert for assistance with PLC analyses. This work was supported by a grant from the American Cancer Society. R. J. S. is an NIH Postdoctoral Trainee. T. S. is an Established Investigator of the American Heart Association. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 1982/12

Y1 - 1982/12

N2 - Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

AB - Two adenovirus type 5 mutants were constructed to probe the function of the virus-encoded RNA polymerase III transcripts (VA RNAs). Each mutant fails to synthesize one of the two VA RNA species. The variant that does not produce the minor VAII species grows normally. The mutant that cannot synthesize the major VAI species grows more poorly than its parent. Analysis of the mutant's growth defect indicates that the adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection.

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Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

Abstract

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