Adenovirus VAI RNA facilitates the initiation of translation in virus-infected cells

Robert J. Schneider, Cary Weinberger, Thomas Shenk

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The adenovirus VAI RNA is a small polymerase III-transcribed species that is required for optimal translation of mRNAs late after infection. Mutant d1331 fails to produce this RNA species and, as a result, grows poorly. Mutant-infected cells contain normal levels of late mRNAs, but reduced levels of polypeptides are synthesized late after infection. Translational elongation occurs at normal rates in mutant, as compared to wild-type, virus-infected cells. Initiation of translation occurs with reduced efficiency in d1331-infected cells. VAI RNA is required for formation of a stable 48S preinitiation complex and very likely functions to facilitate the interaction between 43S preinitiation complex and mRNA to form the 48S species.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalCell
Volume37
Issue number1
DOIs
StatePublished - May 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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