@article{7f094e092de54c82bf6a1258f648563e,
title = "Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase",
abstract = "The VAI RNA of adenovirus is a small, RNA polymerase III-transcribed species required for efficient translation of host cell and viral mRNAs late after infection. The growth of a viral mutant that is unable to produce the RNA is inhibited by interferon, while wild-type virus is not affected. VAI RNA prevents activation of the interferon-induced P1 eIF-2α kinase. This inhibition can be reproduced in extracts of interferon-treated cells where purified VAI RNA prevents activation of latent kinase by double-stranded RNA.",
author = "Jan Kitajewski and Schneider, {Robert J.} and Brian Safer and Munemitsu, {Susan M.} and Samuel, {Charles E.} and Bayar Thimmappaya and Thomas Shenk",
note = "Funding Information: We thank S. Pestka (Roche Institute of Molecular Biology) for a gift of human aA-interferon. This work was supported by a grant from the American Cancer Society (MV-45) to T. Shenk and grants from the National Institutes of Health to C. E. Samuel (Al 12520 and Al 20811) and B. Thimmappaya (Al 18029). J. Kitajewski is a predoctoral trainee of the National institute of General Medical Sciences (GM 07388), R. J. Schneider was a postdoctoral fellow of the National Cancer Institute (CAO7227), 8. Thimmappaya is an Established Investigator of the American Heart Association, and T. Shenk is an American Cancer Society Research Professor.",
year = "1986",
month = apr,
day = "25",
doi = "10.1016/0092-8674(86)90383-1",
language = "English (US)",
volume = "45",
pages = "195--200",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}