Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

Jan Kitajewski, Robert J. Schneider, Brian Safer, Susan M. Munemitsu, Charles E. Samuel, Bayar Thimmappaya, Thomas Shenk

Research output: Contribution to journalArticle

244 Scopus citations

Abstract

The VAI RNA of adenovirus is a small, RNA polymerase III-transcribed species required for efficient translation of host cell and viral mRNAs late after infection. The growth of a viral mutant that is unable to produce the RNA is inhibited by interferon, while wild-type virus is not affected. VAI RNA prevents activation of the interferon-induced P1 eIF-2α kinase. This inhibition can be reproduced in extracts of interferon-treated cells where purified VAI RNA prevents activation of latent kinase by double-stranded RNA.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalCell
Volume45
Issue number2
DOIs
StatePublished - Apr 25 1986

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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