Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73

Fumihiro Higashino, James M. Pipas, Thomas Shenk

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Recently, several proteins have been identified that are related in their sequence to the p53 tumor-suppressor protein. One of these proteins, which is termed p73, exhibits sequence homology to the p53 transcriptional activation, DNA binding, and oligomerization domains. The adenovirus E1B 55- kDa protein, the adenovirus E4orf6 protein, and SV40 T antigen each can bind to p53 and inhibit p53 function. Here we demonstrate that the adenovirus E4orf6 protein, but not the E1B 55-kDa protein or T antigen, interacts with p73. The E4orf6 protein inhibits p73-mediated transcriptional activation and cell killing in a manner similar to its effect on p53. Thus, only a subset of viral oncoproteins that antagonize p53 function also interacts with the related p73 protein.

Original languageEnglish (US)
Pages (from-to)15683-15687
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume95
Issue number26
DOIs
StatePublished - Dec 22 1998

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73'. Together they form a unique fingerprint.

  • Cite this