Adenovirus E1B 55-M(r) polypeptide facilitates timely cytoplasmic accumulation of adeno-associated virus mRNAs

R. J. Samulski, T. Shenk

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Adenovirus provides helper functions that facilitate replication of adeno-associated virus (AAV). Both the adenovirus E1B 55-M(r) and E4 34-M(r) polypeptides are required for efficient and timely accumulation of AAV mRNA, proteins, and DNA. The E1B 55-M(r) polypeptide is also required for rescue of the integrated AAV genome in Detroit 6-D5 cells in a normal time frame. All of these effects probably result from a single, primary delay in AAV mRNA accumulation. The AAV helper function provided by the E1B 55-M(r) and E4 34-M(r) polypeptides appears to closely parallel their normal role in the adenovirus replication cycle.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalJournal of virology
Volume62
Issue number1
DOIs
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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