Transcription of adenoviral early genes is activated by viral E1A gene products. Four of the five early genes contain sequence homologies to the cAMP-inducible element identified in cellular genes. Co-purification and competition assays demonstrated that the adenovirus and cAMP-inducible transcriptional control regions bind the same factor or factors. Since the binding sites map to regions necessary for transcription of the three adenoviral early genes whose control regions were analyzed, it is likely that the activities play a role in their transcription.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - 1988|
All Science Journal Classification (ASJC) codes