Adenoviral control regions activated by E1A and the cAMP response element bind to the same factor

S. Hardy, T. Shenk

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Transcription of adenoviral early genes is activated by viral E1A gene products. Four of the five early genes contain sequence homologies to the cAMP-inducible element identified in cellular genes. Co-purification and competition assays demonstrated that the adenovirus and cAMP-inducible transcriptional control regions bind the same factor or factors. Since the binding sites map to regions necessary for transcription of the three adenoviral early genes whose control regions were analyzed, it is likely that the activities play a role in their transcription.

Original languageEnglish (US)
Pages (from-to)4171-4175
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number12
DOIs
StatePublished - 1988

All Science Journal Classification (ASJC) codes

  • General

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