Adaptive hitchhiking effects on genome variability

P. Andolfatto

Research output: Contribution to journalReview articlepeer-review

143 Scopus citations


The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave 'footprints' in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. Accounting for the effects of population structure and history poses a challenge for future investigations.

Original languageEnglish (US)
Pages (from-to)635-641
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number6
StatePublished - Dec 1 2001

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


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