Acute infection induces a metastatic niche: A double menace for cancer patients

Heath A. Smith; Yibin Kang

doi:10.1158/1078-0432.CCR-13-1524

Acute infection induces a metastatic niche: A double menace for cancer patients

Heath A. Smith
, Yibin Kang

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.

Original language	English (US)
Pages (from-to)	4547-4549
Number of pages	3
Journal	Clinical Cancer Research
Volume	19
Issue number	17
DOIs	https://doi.org/10.1158/1078-0432.CCR-13-1524
State	Published - Sep 1 2013

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1158/1078-0432.CCR-13-1524

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title = "Acute infection induces a metastatic niche: A double menace for cancer patients",

abstract = "Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.",

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AU - Smith, Heath A.

AU - Kang, Yibin

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N2 - Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.

AB - Tumor-derived factors can induce a premetastatic niche, yet little is known about how metastatic microenvironments are influenced by external insults, such as acute infections commonly seen in patients with cancer. New findings reveal increased metastasis to the lung after acute bacterial infection via the CXCR4/ubiquitin axis, suggesting new targets for antimetastasis therapeutics.

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UR - https://www.scopus.com/pages/publications/84883484949#tab=citedBy

U2 - 10.1158/1078-0432.CCR-13-1524

DO - 10.1158/1078-0432.CCR-13-1524

M3 - Article

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SN - 1078-0432

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EP - 4549

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 17

ER -

Acute infection induces a metastatic niche: A double menace for cancer patients

Abstract

All Science Journal Classification (ASJC) codes

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