Activity of serotonergic neurons in behaving animals

Barry L. Jacobs, Casimir A. Fornal

Research output: Contribution to journalArticlepeer-review

285 Scopus citations


Brain serotonergic neurons display a distinctive slow and regular discharge pattern in behaving animals. This activity gradually declines across the arousal-waking sleep cycle, becoming virtually silent during rapid eye movement sleep. The activity of these neurons, in both the pontine and medullary groups, is generally unresponsive to a variety of physiological challenges or stressors. However, these neurons are activated in association with increased muscle tone/tonic motor activity, especially if the motor activity is in the repetitive or central pattern generator mode. We interpret these data within the following theoretical framework. The primary function of the brain serotonergicsystem is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g., during orientation to salient stimuli), this disfacilitates motor function and disinhibits sensory information processing. It is within this context that serotonin exerts its well-known effects on pain, feeding, memory, mood, etc.

Original languageEnglish (US)
Pages (from-to)9S-15S
StatePublished - Aug 1999

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology


  • Cats
  • Motor activity
  • Neuronal activity
  • Raphe
  • Serotonin
  • Stress


Dive into the research topics of 'Activity of serotonergic neurons in behaving animals'. Together they form a unique fingerprint.

Cite this