TY - JOUR
T1 - Activity of medullary serotonergic neurons in freely moving animals
AU - Jacobs, Barry L.
AU - Martín-Cora, Francisco J.
AU - Fornal, Casimir A.
N1 - Funding Information:
The authors’ research was supported by Grant MH-23433 from the National Institute of Mental Health. F.J.M.C. was a recipient of N.A.T.O. postdoctoral award and a Formación de Personal Investigador postdoctoral fellowship from the Spanish Government.
PY - 2002/10
Y1 - 2002/10
N2 - In the mammalian brain, serotonergic neurons in the medulla (n. raphe magnus, obscurus, and pallidus) send dense projections into the spinal cord, especially to the dorsal horn, intermediolateral column, and ventral horn. We have conducted a series of studies examining the single unit activity of these neurons in behaving cats. The experiments were directed at determining whether changes in unit activity were related to pain (n. raphe magnus), autonomic activity (n. raphe obscurus and pallidus), or motor activity (n. raphe obscurus and pallidus). The strongest relationship was between neuronal activity and motor output, especially tonic and repetitive motor activity. We hypothesize that the primary functions of this motor-related activity are to facilitate motor output, suppress processing of some forms of afferent activity, and to coordinate autonomic functioning with the current motor demand.
AB - In the mammalian brain, serotonergic neurons in the medulla (n. raphe magnus, obscurus, and pallidus) send dense projections into the spinal cord, especially to the dorsal horn, intermediolateral column, and ventral horn. We have conducted a series of studies examining the single unit activity of these neurons in behaving cats. The experiments were directed at determining whether changes in unit activity were related to pain (n. raphe magnus), autonomic activity (n. raphe obscurus and pallidus), or motor activity (n. raphe obscurus and pallidus). The strongest relationship was between neuronal activity and motor output, especially tonic and repetitive motor activity. We hypothesize that the primary functions of this motor-related activity are to facilitate motor output, suppress processing of some forms of afferent activity, and to coordinate autonomic functioning with the current motor demand.
KW - 5-Hydroxytryptamine (5-HT)
KW - Cat
KW - Fatigue
KW - Motor activity
KW - Pain
KW - Raphe
KW - Serotonin
KW - Spinal cord
KW - Sympathetic activity
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U2 - 10.1016/S0165-0173(02)00187-X
DO - 10.1016/S0165-0173(02)00187-X
M3 - Review article
C2 - 12589905
AN - SCOPUS:0036824699
SN - 0165-0173
VL - 40
SP - 45
EP - 52
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 1-3
ER -