TY - JOUR
T1 - Activity-based sensing fluorescent probes for iron in biological systems
AU - Aron, Allegra T.
AU - Reeves, Audrey G.
AU - Chang, Christopher J.
N1 - Publisher Copyright:
© 2017
PY - 2018/4
Y1 - 2018/4
N2 - Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
AB - Iron is an essential nutrient for life, and its capacity to cycle between different oxidation states is required for processes spanning oxygen transport and respiration to nucleotide synthesis and epigenetic regulation. However, this same redox ability also makes iron, if not regulated properly, a potentially dangerous toxin that can trigger oxidative stress and damage. New methods that enable monitoring of iron in living biological systems, particularly in labile Fe2+ forms, can help identify its contributions to physiology, aging, and disease. In this review, we summarize recent developments in activity-based sensing (ABS) probes for fluorescence Fe2+ detection.
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U2 - 10.1016/j.cbpa.2017.12.010
DO - 10.1016/j.cbpa.2017.12.010
M3 - Review article
C2 - 29306820
AN - SCOPUS:85040018458
SN - 1367-5931
VL - 43
SP - 113
EP - 118
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -