Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development

Elizabeth Gould, Patima Tanapat, Bruce S. McEwen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalDevelopmental Brain Research
Volume101
Issue number1-2
DOIs
StatePublished - Jul 1997

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Keywords

  • Adrenal steroid receptor
  • Cell death
  • Dentate gyms
  • Development
  • RU28362
  • TUNEL

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