Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development

Elizabeth Gould; Patima Tanapat; Bruce S. McEwen

doi:10.1016/S0165-3806(97)00023-0

Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development

Elizabeth Gould, Patima Tanapat, Bruce S. McEwen

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.

Original language	English (US)
Pages (from-to)	265-268
Number of pages	4
Journal	Developmental Brain Research
Volume	101
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-3806(97)00023-0
State	Published - Jul 1997

All Science Journal Classification (ASJC) codes

Developmental Neuroscience
Developmental Biology

Keywords

Adrenal steroid receptor
Cell death
Dentate gyms
Development
RU28362
TUNEL

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10.1016/S0165-3806(97)00023-0

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abstract = "To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.",

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AU - Tanapat, Patima

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AB - To determine whether activation of the type 2 adrenal steroid receptor affects granule cell death in the developing dentate gyrus, we treated rat pups with the type 2 receptor agonist RU28362 and examined degenerating cells using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) and Nissl staining. RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration.

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KW - Development

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KW - TUNEL

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Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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