Activation of C-H bonds via the merger of photoredox and organocatalysis: A coupling of benzylic ethers with schiff bases

Dominik Hager, David W.C. Macmillan

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

The photoredox-mediated coupling of benzylic ethers with Schiff bases has been accomplished. Direct benzylic C-H activation by a combination of a thiol catalyst with an iridium photocatalyst and subsequent radical-radical coupling with secondary aldimines affords a variety of β-amino ether products in good to excellent yields. Mechanistic studies suggest that a reductive quenching pathway of the photocatalyst is operable.

Original languageEnglish (US)
Pages (from-to)16986-16989
Number of pages4
JournalJournal of the American Chemical Society
Volume136
Issue number49
DOIs
StatePublished - Dec 10 2014

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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