Activation of 5-HT neuronal activity during motor behavior

Barry L. Jacobs; Casimir A. Fornal

doi:10.1016/1044-5765(95)90004-7

Activation of 5-HT neuronal activity during motor behavior

Barry L. Jacobs, Casimir A. Fornal

Psychology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Brain serotonin (5-HT) neuronal activity is activated preferentially in association with motor activity. This is especially clear during changes in tonic motor output and during repetitive responses mediated by central pattern generators, such as locomotion, respiration and chewing. These and other data support the hypothesis that the primary function of the brain serotonin system is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g. during focussed attention), this disfacilitates motor function and disinhibits sensory information processing.

Original language	English (US)
Pages (from-to)	401-408
Number of pages	8
Journal	Seminars in Neuroscience
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/1044-5765(95)90004-7
State	Published - Dec 1995

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

central pattern generator
motor activity
raphe
serotonin
single unit activity

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10.1016/1044-5765(95)90004-7

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title = "Activation of 5-HT neuronal activity during motor behavior",

abstract = "Brain serotonin (5-HT) neuronal activity is activated preferentially in association with motor activity. This is especially clear during changes in tonic motor output and during repetitive responses mediated by central pattern generators, such as locomotion, respiration and chewing. These and other data support the hypothesis that the primary function of the brain serotonin system is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g. during focussed attention), this disfacilitates motor function and disinhibits sensory information processing.",

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author = "Jacobs, {Barry L.} and Fornal, {Casimir A.}",

note = "Funding Information: The authors{\textquoteright} research described in this article was sup ported by grants from the National Institute of Mental Health (MH-23433) and the Air Force Office of Scientific Research (AFOSR-0294).",

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AU - Jacobs, Barry L.

AU - Fornal, Casimir A.

N1 - Funding Information: The authors’ research described in this article was sup ported by grants from the National Institute of Mental Health (MH-23433) and the Air Force Office of Scientific Research (AFOSR-0294).

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N2 - Brain serotonin (5-HT) neuronal activity is activated preferentially in association with motor activity. This is especially clear during changes in tonic motor output and during repetitive responses mediated by central pattern generators, such as locomotion, respiration and chewing. These and other data support the hypothesis that the primary function of the brain serotonin system is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g. during focussed attention), this disfacilitates motor function and disinhibits sensory information processing.

AB - Brain serotonin (5-HT) neuronal activity is activated preferentially in association with motor activity. This is especially clear during changes in tonic motor output and during repetitive responses mediated by central pattern generators, such as locomotion, respiration and chewing. These and other data support the hypothesis that the primary function of the brain serotonin system is to facilitate motor output. Concurrently, the system coordinates autonomic and neuroendocrine function with the present motor demand, and inhibits information processing in various sensory pathways. Reciprocally, when the serotonin system is briefly inactivated (e.g. during focussed attention), this disfacilitates motor function and disinhibits sensory information processing.

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Activation of 5-HT neuronal activity during motor behavior

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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