Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics

M. N. Shneider; A. A. Voronin; A. M. Zheltikov

doi:10.1103/PhysRevE.81.031926

Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics

M. N. Shneider, A. A. Voronin, A. M. Zheltikov

Mechanical & Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an action-potential- sensitive second-harmonic response of membrane-bound chromophores. This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules.

Original language	English (US)
Article number	031926
Journal	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume	81
Issue number	3
DOIs	https://doi.org/10.1103/PhysRevE.81.031926
State	Published - Mar 31 2010

All Science Journal Classification (ASJC) codes

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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10.1103/PhysRevE.81.031926

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abstract = "The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an action-potential- sensitive second-harmonic response of membrane-bound chromophores. This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules.",

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AB - The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an action-potential- sensitive second-harmonic response of membrane-bound chromophores. This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules.

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Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics

Abstract

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