Actin and Rho GTPases in herpesvirus biology

Herman W. Favoreel; L. W. Enquist; Becket Feierbach

doi:10.1016/j.tim.2007.08.003

Actin and Rho GTPases in herpesvirus biology

Herman W. Favoreel
, L. W. Enquist
, Becket Feierbach

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.

Original language	English (US)
Pages (from-to)	426-433
Number of pages	8
Journal	Trends in Microbiology
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/j.tim.2007.08.003
State	Published - Sep 2007

All Science Journal Classification (ASJC) codes

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

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10.1016/j.tim.2007.08.003

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@article{bae189b198664d5a90fbd89c085b379c,

title = "Actin and Rho GTPases in herpesvirus biology",

abstract = "Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.",

author = "Favoreel, \{Herman W.\} and Enquist, \{L. W.\} and Becket Feierbach",

note = "Funding Information: We thank Silvia Piccinotti for the drawings used in this review. L.E. and B.F. are supported by the National Institute of Neurological Disorders and Stroke (NIH-NINDS; grant R01 33506) and the Dana Research Foundation. H.F. is supported by research grants from the Research Foundation – Flanders (F.W.O. Vlaanderen, grant nr. G.0196.06) and a Concerted Research Action fund of Ghent University. We thank all the present and past members of the Favoreel research group and the members of the Enquist laboratory. In particular, we would like to mention all the hard work of Geert Van Minnebruggen, Nick De Regge, C{\'e}line Van den Broeke, Matthias Deruelle, Sarah Glorieux and Silvia Piccinotti related to this topic. We also thank Hans Nauwynck for many fruitful discussions. We apologize to any colleagues whose work we were unable to mention because of space constraints.",

year = "2007",

month = sep,

doi = "10.1016/j.tim.2007.08.003",

language = "English (US)",

volume = "15",

pages = "426--433",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd",

number = "9",

}

TY - JOUR

T1 - Actin and Rho GTPases in herpesvirus biology

AU - Favoreel, Herman W.

AU - Enquist, L. W.

AU - Feierbach, Becket

N1 - Funding Information: We thank Silvia Piccinotti for the drawings used in this review. L.E. and B.F. are supported by the National Institute of Neurological Disorders and Stroke (NIH-NINDS; grant R01 33506) and the Dana Research Foundation. H.F. is supported by research grants from the Research Foundation – Flanders (F.W.O. Vlaanderen, grant nr. G.0196.06) and a Concerted Research Action fund of Ghent University. We thank all the present and past members of the Favoreel research group and the members of the Enquist laboratory. In particular, we would like to mention all the hard work of Geert Van Minnebruggen, Nick De Regge, Céline Van den Broeke, Matthias Deruelle, Sarah Glorieux and Silvia Piccinotti related to this topic. We also thank Hans Nauwynck for many fruitful discussions. We apologize to any colleagues whose work we were unable to mention because of space constraints.

PY - 2007/9

Y1 - 2007/9

N2 - Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.

AB - Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.

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UR - https://www.scopus.com/pages/publications/34548516188#tab=citedBy

U2 - 10.1016/j.tim.2007.08.003

DO - 10.1016/j.tim.2007.08.003

M3 - Review article

C2 - 17764949

AN - SCOPUS:34548516188

SN - 0966-842X

VL - 15

SP - 426

EP - 433

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 9

ER -

Actin and Rho GTPases in herpesvirus biology

Abstract

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