Actin and Rho GTPases in herpesvirus biology

Herman W. Favoreel, L. W. Enquist, Becket Feierbach

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Viruses have evolved a variety of interactions with host cells to create an optimal niche for viral replication, persistence and spread. The actin cytoskeleton of the host cell and actin-regulating Rho GTPase signaling pathways can be involved in several of these interactions. This review focuses on recent findings on herpesvirus interactions with actin and Rho GTPases during viral entry, replication in the nucleus and egress. Unraveling these often fascinating interactions might also provide additional insights into sometimes poorly known aspects of actin biology (e.g. its role in the nucleus) and in the development of novel antiviral therapies.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalTrends in Microbiology
Volume15
Issue number9
DOIs
StatePublished - Sep 1 2007

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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