Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

Glen Liszczak; Katharine L. Diehl; Geoffrey P. Dann; Tom W. Muir

doi:10.1038/s41589-018-0097-1

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

Glen Liszczak, Katharine L. Diehl, Geoffrey P. Dann, Tom W. Muir

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.

Original language	English (US)
Pages (from-to)	837-840
Number of pages	4
Journal	Nature Chemical Biology
Volume	14
Issue number	9
DOIs	https://doi.org/10.1038/s41589-018-0097-1
State	Published - Sep 1 2018

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Access to Document

10.1038/s41589-018-0097-1

Cite this

@article{1a6d2f4261f04271965bcdcf6123404c,

title = "Acetylation blocks DNA damage–induced chromatin ADP-ribosylation",

abstract = "Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.",

author = "Glen Liszczak and Diehl, {Katharine L.} and Dann, {Geoffrey P.} and Muir, {Tom W.}",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = sep,

day = "1",

doi = "10.1038/s41589-018-0097-1",

language = "English (US)",

volume = "14",

pages = "837--840",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "Nature Research",

number = "9",

}

TY - JOUR

T1 - Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

AU - Liszczak, Glen

AU - Diehl, Katharine L.

AU - Dann, Geoffrey P.

AU - Muir, Tom W.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.

AB - Recent studies report serine ADP-ribosylation on nucleosomes during the DNA damage response. We unveil histone H3 serine 10 as the primary acceptor residue for chromatin ADP-ribosylation and find that specific histone acetylation marks block this activity. Our results provide a molecular explanation for the well-documented phenomenon of rapid deacetylation at DNA damage sites and support the combinatorial application of PARP and HDAC inhibitors for the treatment of PARP-dependent cancers.

UR - http://www.scopus.com/inward/record.url?scp=85049926812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049926812&partnerID=8YFLogxK

U2 - 10.1038/s41589-018-0097-1

DO - 10.1038/s41589-018-0097-1

M3 - Article

C2 - 30013063

AN - SCOPUS:85049926812

SN - 1552-4450

VL - 14

SP - 837

EP - 840

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 9

ER -

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this