Acetaminophen toxicity in children

Robert M. Ward; Brian A. Bates; William E. Benitz; David J. Burchfield; John C. Ring; Richard P. Walls; Philip D. Walson; John Alexander; Donald R. Bennett; Therese Cvetkovich; Owen R. Hagino; Stuart M. MacLeod; Siddika Mithani; Joseph Mulinare; Laura E. Riley; Sumner J. Yaffe; Charles J. Coté; Eli O. Meltzer; Gregory L. Kearns; D. Gail McCarver; Daniel A. Notterman; Stephen J. Spielberg; Raymond J. Koteras

doi:10.1542/peds.108.4.1020

Acetaminophen toxicity in children

Robert M. Ward, Brian A. Bates, William E. Benitz, David J. Burchfield, John C. Ring, Richard P. Walls, Philip D. Walson, John Alexander, Donald R. Bennett, Therese Cvetkovich, Owen R. Hagino, Stuart M. MacLeod, Siddika Mithani, Joseph Mulinare, Laura E. Riley, Sumner J. Yaffe, Charles J. Coté, Eli O. Meltzer, Gregory L. Kearns, D. Gail McCarverDaniel A. Notterman, Stephen J. Spielberg, Raymond J. Koteras

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

158 Scopus citations

Abstract

Acetaminophen is widely used in children, because its safety and efficacy are well established. Although the risk of developing toxic reactions to acetaminophen appears to be lower in children than in adults, such reactions occur in pediatric patients from intentional overdoses. Less frequently, acetaminophen toxicity is attributable to unintended inappropriate dosing or the failure to recognize children at increased risk in whom standard acetaminophen doses have been administered. Because the symptoms of acetaminophen intoxication are nonspecific, the diagnosis and treatment of acetaminophen intoxication are more likely to be delayed in unintentional cases of toxicity. This statement describes situations and conditions that may contribute to acetaminophen toxicity not associated with suicidal intentions.

Original language	English (US)
Pages (from-to)	1020-1024
Number of pages	5
Journal	Pediatrics
Volume	108
Issue number	4
DOIs	https://doi.org/10.1542/peds.108.4.1020
State	Published - 2001

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1542/peds.108.4.1020

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Ward, R. M., Bates, B. A., Benitz, W. E., Burchfield, D. J., Ring, J. C., Walls, R. P., Walson, P. D., Alexander, J., Bennett, D. R., Cvetkovich, T., Hagino, O. R., MacLeod, S. M., Mithani, S., Mulinare, J., Riley, L. E., Yaffe, S. J., Coté, C. J., Meltzer, E. O., Kearns, G. L., ... Koteras, R. J. (2001). Acetaminophen toxicity in children. Pediatrics, 108(4), 1020-1024. https://doi.org/10.1542/peds.108.4.1020

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title = "Acetaminophen toxicity in children",

abstract = "Acetaminophen is widely used in children, because its safety and efficacy are well established. Although the risk of developing toxic reactions to acetaminophen appears to be lower in children than in adults, such reactions occur in pediatric patients from intentional overdoses. Less frequently, acetaminophen toxicity is attributable to unintended inappropriate dosing or the failure to recognize children at increased risk in whom standard acetaminophen doses have been administered. Because the symptoms of acetaminophen intoxication are nonspecific, the diagnosis and treatment of acetaminophen intoxication are more likely to be delayed in unintentional cases of toxicity. This statement describes situations and conditions that may contribute to acetaminophen toxicity not associated with suicidal intentions.",

author = "Ward, {Robert M.} and Bates, {Brian A.} and Benitz, {William E.} and Burchfield, {David J.} and Ring, {John C.} and Walls, {Richard P.} and Walson, {Philip D.} and John Alexander and Bennett, {Donald R.} and Therese Cvetkovich and Hagino, {Owen R.} and MacLeod, {Stuart M.} and Siddika Mithani and Joseph Mulinare and Riley, {Laura E.} and Yaffe, {Sumner J.} and Cot{\'e}, {Charles J.} and Meltzer, {Eli O.} and Kearns, {Gregory L.} and McCarver, {D. Gail} and Notterman, {Daniel A.} and Spielberg, {Stephen J.} and Koteras, {Raymond J.}",

year = "2001",

doi = "10.1542/peds.108.4.1020",

language = "English (US)",

volume = "108",

pages = "1020--1024",

journal = "Pediatrics",

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publisher = "American Academy of Pediatrics",

number = "4",

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Ward, RM, Bates, BA, Benitz, WE, Burchfield, DJ, Ring, JC, Walls, RP, Walson, PD, Alexander, J, Bennett, DR, Cvetkovich, T, Hagino, OR, MacLeod, SM, Mithani, S, Mulinare, J, Riley, LE, Yaffe, SJ, Coté, CJ, Meltzer, EO, Kearns, GL, McCarver, DG, Notterman, DA, Spielberg, SJ & Koteras, RJ 2001, 'Acetaminophen toxicity in children', Pediatrics, vol. 108, no. 4, pp. 1020-1024. https://doi.org/10.1542/peds.108.4.1020

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T1 - Acetaminophen toxicity in children

AU - Ward, Robert M.

AU - Bates, Brian A.

AU - Benitz, William E.

AU - Burchfield, David J.

AU - Ring, John C.

AU - Walls, Richard P.

AU - Walson, Philip D.

AU - Alexander, John

AU - Bennett, Donald R.

AU - Cvetkovich, Therese

AU - Hagino, Owen R.

AU - MacLeod, Stuart M.

AU - Mithani, Siddika

AU - Mulinare, Joseph

AU - Riley, Laura E.

AU - Yaffe, Sumner J.

AU - Coté, Charles J.

AU - Meltzer, Eli O.

AU - Kearns, Gregory L.

AU - McCarver, D. Gail

AU - Notterman, Daniel A.

AU - Spielberg, Stephen J.

AU - Koteras, Raymond J.

PY - 2001

Y1 - 2001

N2 - Acetaminophen is widely used in children, because its safety and efficacy are well established. Although the risk of developing toxic reactions to acetaminophen appears to be lower in children than in adults, such reactions occur in pediatric patients from intentional overdoses. Less frequently, acetaminophen toxicity is attributable to unintended inappropriate dosing or the failure to recognize children at increased risk in whom standard acetaminophen doses have been administered. Because the symptoms of acetaminophen intoxication are nonspecific, the diagnosis and treatment of acetaminophen intoxication are more likely to be delayed in unintentional cases of toxicity. This statement describes situations and conditions that may contribute to acetaminophen toxicity not associated with suicidal intentions.

AB - Acetaminophen is widely used in children, because its safety and efficacy are well established. Although the risk of developing toxic reactions to acetaminophen appears to be lower in children than in adults, such reactions occur in pediatric patients from intentional overdoses. Less frequently, acetaminophen toxicity is attributable to unintended inappropriate dosing or the failure to recognize children at increased risk in whom standard acetaminophen doses have been administered. Because the symptoms of acetaminophen intoxication are nonspecific, the diagnosis and treatment of acetaminophen intoxication are more likely to be delayed in unintentional cases of toxicity. This statement describes situations and conditions that may contribute to acetaminophen toxicity not associated with suicidal intentions.

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SN - 0031-4005

VL - 108

SP - 1020

EP - 1024

JO - Pediatrics

JF - Pediatrics

IS - 4

ER -

Acetaminophen toxicity in children

Abstract

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