Accessing the Hidden Majority of Marine Natural Products through Metagenomics

Mohamed S. Abou Donia, Duane E. Ruffner, Sheng Cao, Eric W. Schmidt

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Tiny marine animals represent an untapped reservoir for undiscovered, bioactive natural products. However, their small size and extreme chemical variability preclude traditional chemical approaches to discovering new bioactive compounds. Here, we use a metagenomic method to directly discover and rapidly access cyanobactin class natural products from these variable samples, and provide proof-of-concept for genome-based discovery and supply of marine natural products. We also address practical optimization of complex, multistep ribosomal peptide pathways in heterologous hosts, which is still very challenging. The resulting methods and concepts will be applicable to ribosomal peptide and other biosynthetic pathways.

Original languageEnglish (US)
Pages (from-to)1230-1236
Number of pages7
JournalChemBioChem
Volume12
Issue number8
DOIs
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Keywords

  • Drug discovery
  • Natural products
  • Nonribosomal peptides
  • Ribosomal peptides
  • Symbiosis

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