Acceleration of the emergence of bacterial antibiotic resistance

Qiucen Zhang, David Liao, Robert Hamilton Austin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We designed and fabricated a two-dimensional microfluidic device to mimic the heterogeneous environment in naturally occurring bacteria culture. We demonstrated that it is possible to fix resistance to the powerful antibiotic ciprofloxacin (Cipro) in E. coli within 10 hours through a combination of antibiotic gradients and bacterial metapopulation. Simulation based on a deterministic model shows the evolution is accelerated in a slanted fitness landscape, compared to uniformly high and uniformly low fitness landscape.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages1481-1483
Number of pages3
StatePublished - Dec 1 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Keywords

  • Bacteria
  • Evolution
  • Microfluidic
  • Resistance

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  • Cite this

    Zhang, Q., Liao, D., & Austin, R. H. (2011). Acceleration of the emergence of bacterial antibiotic resistance. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 1481-1483). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).