@inproceedings{b4f8eb67f9884811a9b040b9da5f4d4c,
title = "Acceleration of the emergence of bacterial antibiotic resistance",
abstract = "We designed and fabricated a two-dimensional microfluidic device to mimic the heterogeneous environment in naturally occurring bacteria culture. We demonstrated that it is possible to fix resistance to the powerful antibiotic ciprofloxacin (Cipro) in E. coli within 10 hours through a combination of antibiotic gradients and bacterial metapopulation. Simulation based on a deterministic model shows the evolution is accelerated in a slanted fitness landscape, compared to uniformly high and uniformly low fitness landscape.",
keywords = "Bacteria, Evolution, Microfluidic, Resistance",
author = "Qiucen Zhang and David Liao and Austin, {Robert H.}",
year = "2011",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "1481--1483",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}