Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments

Qiucen Zhang, Guillaume Lambert, David Liao, Hyunsung Kim, Kristelle Robin, Chih Kuan Tung, Nader Pourmand, Robert H. Austin

Research output: Contribution to journalArticle

291 Scopus citations

Abstract

The emergence of bacterial antibiotic resistance is a growing problem, yet the variables that influence the rate of emergence of resistance are not well understood. In a microfluidic device designed to mimic naturally occurring bacterial niches, resistance of Escherichia coli to the antibiotic ciprofloxacin developed within 10 hours. Resistance emerged with as few as 100 bacteria in the initial inoculation. Whole-genome sequencing of the resistant organisms revealed that four functional single-nucleotide polymorphisms attained fixation. Knowledge about the rapid emergence of antibiotic resistance in the heterogeneous conditions within the mammalian body may be helpful in understanding the emergence of drug resistance during cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)1764-1767
Number of pages4
JournalScience
Volume333
Issue number6050
DOIs
StatePublished - Oct 23 2011

All Science Journal Classification (ASJC) codes

  • General

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    Zhang, Q., Lambert, G., Liao, D., Kim, H., Robin, K., Tung, C. K., Pourmand, N., & Austin, R. H. (2011). Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. Science, 333(6050), 1764-1767. https://doi.org/10.1126/science.1208747