@article{46dae4b1612b4213bd4acbccdfe38497,
title = "Accelerating reaction generality and mechanistic insight through additive mapping",
abstract = "Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. We developed an additive mapping approach that rapidly expands the utility of synthetic methods while generating concurrent mechanistic insight. Validation of this approach on the metallaphotoredox decarboxylative arylation resulted in the discovery of a phthalimide ligand additive that overcomes many lingering limitations of this reaction and has important mechanistic implications for nickel-catalyzed cross-couplings.",
author = "{Prieto Kullmer}, {Cesar N.} and Kautzky, {Jacob A.} and Krska, {Shane W.} and Timothy Nowak and Dreher, {Spencer D.} and MacMillan, {David W.C.}",
note = "Funding Information: This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (award R35GM134897-02) and by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.; Kenilworth, NJ, USA; Pfizer; Janssen; Bristol-Myers Squibb; Genentech; and Celgene. C.N.P.K. was supported by Princeton University, E. Taylor, and the Taylor family by an Edward C. Taylor fellowship. J.A.K. was supported by a predoctoral fellowship (award DGE 1656466) from the National Science Foundation. Publisher Copyright: Copyright {\textcopyright} 2022 The Authors",
year = "2022",
month = apr,
day = "29",
doi = "10.1126/science.abn1885",
language = "English (US)",
volume = "376",
pages = "532--539",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6592",
}