Accelerating reaction generality and mechanistic insight through additive mapping

Cesar N. Prieto Kullmer, Jacob A. Kautzky, Shane W. Krska, Timothy Nowak, Spencer D. Dreher, David W.C. MacMillan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Reaction generality is crucial in determining the overall impact and usefulness of synthetic methods. Typical generalization protocols require a priori mechanistic understanding and suffer when applied to complex, less understood systems. We developed an additive mapping approach that rapidly expands the utility of synthetic methods while generating concurrent mechanistic insight. Validation of this approach on the metallaphotoredox decarboxylative arylation resulted in the discovery of a phthalimide ligand additive that overcomes many lingering limitations of this reaction and has important mechanistic implications for nickel-catalyzed cross-couplings.

Original languageEnglish (US)
Pages (from-to)532-539
Number of pages8
JournalScience
Volume376
Issue number6592
DOIs
StatePublished - Apr 29 2022

All Science Journal Classification (ASJC) codes

  • General

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