Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032

Simone Keller; Graeme Nicholson; Carmen Drahl; Erik Sorensen; Hans Peter Fiedler; Roderich D. Süssmuth

doi:10.1038/ja.2007.54

Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032

Simone Keller, Graeme Nicholson, Carmen Drahl, Erik Sorensen, Hans Peter Fiedler, Roderich D. Süssmuth

Chemistry

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.

Original language	English (US)
Pages (from-to)	391-394
Number of pages	4
Journal	Journal of Antibiotics
Volume	60
Issue number	6
DOIs	https://doi.org/10.1038/ja.2007.54
State	Published - Jun 2007

All Science Journal Classification (ASJC) codes

Drug Discovery
Pharmacology

Keywords

Abyssomicins
Antibiotics
Structure elucidation
Tetronic acid
Verrucosispora

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10.1038/ja.2007.54

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title = "Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032",

abstract = "Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.",

keywords = "Abyssomicins, Antibiotics, Structure elucidation, Tetronic acid, Verrucosispora",

author = "Simone Keller and Graeme Nicholson and Carmen Drahl and Erik Sorensen and Fiedler, \{Hans Peter\} and S{\"u}ssmuth, \{Roderich D.\}",

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language = "English (US)",

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AU - Keller, Simone

AU - Nicholson, Graeme

AU - Drahl, Carmen

AU - Sorensen, Erik

AU - Fiedler, Hans Peter

AU - Süssmuth, Roderich D.

PY - 2007/6

Y1 - 2007/6

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AB - Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.

KW - Abyssomicins

KW - Antibiotics

KW - Structure elucidation

KW - Tetronic acid

KW - Verrucosispora

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ER -

Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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