A twist in Pitx2 regulation of gut looping

Triveni Menon; Rebecca D. Burdine

doi:10.1016/j.devcel.2022.10.006

A twist in Pitx2 regulation of gut looping

Triveni Menon, Rebecca D. Burdine

Molecular Biology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a “brake” to counteract BMP4 signaling on the right.

Original language	English (US)
Pages (from-to)	2445-2446
Number of pages	2
Journal	Developmental cell
Volume	57
Issue number	21
DOIs	https://doi.org/10.1016/j.devcel.2022.10.006
State	Published - Nov 7 2022

All Science Journal Classification (ASJC) codes

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2022.10.006

Cite this

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title = "A twist in Pitx2 regulation of gut looping",

abstract = "Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a “brake” to counteract BMP4 signaling on the right.",

author = "Triveni Menon and Burdine, \{Rebecca D.\}",

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AU - Burdine, Rebecca D.

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AB - Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a “brake” to counteract BMP4 signaling on the right.

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M3 - Comment/debate

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SN - 1534-5807

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SP - 2445

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JO - Developmental cell

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A twist in Pitx2 regulation of gut looping

Abstract

All Science Journal Classification (ASJC) codes

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