A twist in Pitx2 regulation of gut looping

Triveni Menon, Rebecca D. Burdine

Research output: Contribution to journalComment/debatepeer-review


Asymmetric expression of the transcription factor Pitx2 is important for correct asymmetry in organs during development. In a recent issue of Science, Sanketi et al. find Pitx2 expression directing gut tilting is independent of Nodal and acts as a “brake” to counteract BMP4 signaling on the right.

Original languageEnglish (US)
Pages (from-to)2445-2446
Number of pages2
JournalDevelopmental cell
Issue number21
StatePublished - Nov 7 2022

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • Molecular Biology
  • Cell Biology
  • Developmental Biology


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